Publications at MTSU: (* denotes undergraduate student)
1. M. E. Wright, J. Byrd*, C. He, N. Dunlap "Synthesis of Cyclocaric Acid A and Comparison to Material from Cyclocarya paliurus" J. Nat. Prod. 2014, http://pubs.acs.org/doi/abs/10.1021/np500575q
2. Dunlap, N.; Salyard, T. L. J.; Pathiranage, A. L.; Stubblefield, J.; Pitts, S. L.; Ashley, R. E.; Osheroff, N. “Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers” Bioorg. & Med. Chem. Lett. 2014,
DOI: 10.1016/j.bmcl.2014.10.082
3. N. K. Dunlap, J. Basham*, M. Wright, K. Smith, O. Chapa*, J. Huang*, W. Shelton*, Y. Yatsky* “Synthesis of nitrocyclopropyl peptidomimetics” Tetrahedron Lett. 2013,54, 6596-6598. http://dx.doi.org DOI: 10.1016/j.tetlet.2013.09.106
4. N. Dunlap, L. J. Martin "Discovery-based labs for organic chemistry: overview and effectiveness" ACS Book: Symposia in Print: Advances in Teaching Organic Chemistry, 2012, 1108, 1-11.
5. N. Dunlap, K. R. Lankford, A. L. Pathiranage, J. Taylor*, N. Reddy*, D. Gouger*, P. Singer*, K. Griffin* and J. Reibenspies "Three-step synthesis of cyclopropyl peptidomimetics" Org. Lett. 2011, 13, 4879-4881. http://pubs.acs.org/doi/full/10.1021/ol201828u
6. N. K. Dunlap, J. Drake*, A. Ward*, T.L.J. Salyard and L. Martin "A Concise Synthesis of Enantiomers of 4-Aminobutane-1,2,3-triol" J. Org. Chem. 2008, 73, 2928-2930. http://pubs.acs.org/doi/full/10.1021/jo702647n
7. R. P. Bender, M. J. Jablonsky, M. Shadid, I. Romaine, N. Dunlap, C. Anklin, D. E. Graves and N. Osheroff "Substituents on Etoposide that Interact with Human Topoisomerase IIa in the Binary Enzyme-Drug Complex: Contributions to Etoposide Binding and Activity" Biochemistry 2008, 47, 4501-4509. http://pubs.acs.org/doi/full/10.1021/bi702019z
8. N. K. Dunlap, W. Mergo, J. M. Jones* and L. Martin, "Use of 13C NMR in a Dehydration Experiment for Organic Chemistry" Chem. Educator 2006, 11, 378.
http://chemeducator.org/papers/0011006/11060378nd.htm
9. N. K. Dunlap, W. Mergo, J. M. Jones* and J. D. Carrick*, "A general procedure for a one-pot oxidative cleavage/Wittig reaction of glycols" Tetrahedron Letters 2002, 3923.
http://dx.doi.org doi:10.1016/S0040-4039(02)00661-5
Publications at Roche:
1. N. K. Dunlap, M. Dezube, D. D. Keith and M. Weigele, "1,1-Dicyanomethylcarbacephems: "Synthesis of a Highly Reactive 1,1-Dicyanomethylene-1-dethiacephalosporin", Tetrahedron Letters 1992, 6103.
http://dx.doi.org doi:10.1016/S0040-4039(00)60017-5
2. A. J. Corraz, S. L. Dax, N. K. Dunlap, N. H. Georgopapadakou, D. D. Keith, D. L. Pruess, P. L. Rossman, R. Then, J. Unowsky and C.-C. Wei, "Dual-Action Penems and Carbapenems", J. Med. Chem. 1992, 35, 1828. http://pubs.acs.org/doi/abs/10.1021/jm00088a019
Patents
1. N. K. Dunlap, D. D. Keith and C.-C. Wei, "Antibacterial Penem Compounds", U. S. Patent Application Serial No. 07/630,694.
Funding
August 2003 (PI) $415,879 National Science Foundation
"400 MHz NMR for Research and Training in Chemical Synthesis"
July 2003 (co-PI) $174,443 National Science Foundation
"Hands-on Experiences with NMR in the Undergraduate Chemistry Curriculum"
June 2003 (PI) $105,00` NIH AREA grant,
"Peptidomimetics of D-Ala-D-Ala as Novel Antibacterials"
1. M. E. Wright, J. Byrd*, C. He, N. Dunlap "Synthesis of Cyclocaric Acid A and Comparison to Material from Cyclocarya paliurus" J. Nat. Prod. 2014, http://pubs.acs.org/doi/abs/10.1021/np500575q
2. Dunlap, N.; Salyard, T. L. J.; Pathiranage, A. L.; Stubblefield, J.; Pitts, S. L.; Ashley, R. E.; Osheroff, N. “Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers” Bioorg. & Med. Chem. Lett. 2014,
DOI: 10.1016/j.bmcl.2014.10.082
3. N. K. Dunlap, J. Basham*, M. Wright, K. Smith, O. Chapa*, J. Huang*, W. Shelton*, Y. Yatsky* “Synthesis of nitrocyclopropyl peptidomimetics” Tetrahedron Lett. 2013,54, 6596-6598. http://dx.doi.org DOI: 10.1016/j.tetlet.2013.09.106
4. N. Dunlap, L. J. Martin "Discovery-based labs for organic chemistry: overview and effectiveness" ACS Book: Symposia in Print: Advances in Teaching Organic Chemistry, 2012, 1108, 1-11.
5. N. Dunlap, K. R. Lankford, A. L. Pathiranage, J. Taylor*, N. Reddy*, D. Gouger*, P. Singer*, K. Griffin* and J. Reibenspies "Three-step synthesis of cyclopropyl peptidomimetics" Org. Lett. 2011, 13, 4879-4881. http://pubs.acs.org/doi/full/10.1021/ol201828u
6. N. K. Dunlap, J. Drake*, A. Ward*, T.L.J. Salyard and L. Martin "A Concise Synthesis of Enantiomers of 4-Aminobutane-1,2,3-triol" J. Org. Chem. 2008, 73, 2928-2930. http://pubs.acs.org/doi/full/10.1021/jo702647n
7. R. P. Bender, M. J. Jablonsky, M. Shadid, I. Romaine, N. Dunlap, C. Anklin, D. E. Graves and N. Osheroff "Substituents on Etoposide that Interact with Human Topoisomerase IIa in the Binary Enzyme-Drug Complex: Contributions to Etoposide Binding and Activity" Biochemistry 2008, 47, 4501-4509. http://pubs.acs.org/doi/full/10.1021/bi702019z
8. N. K. Dunlap, W. Mergo, J. M. Jones* and L. Martin, "Use of 13C NMR in a Dehydration Experiment for Organic Chemistry" Chem. Educator 2006, 11, 378.
http://chemeducator.org/papers/0011006/11060378nd.htm
9. N. K. Dunlap, W. Mergo, J. M. Jones* and J. D. Carrick*, "A general procedure for a one-pot oxidative cleavage/Wittig reaction of glycols" Tetrahedron Letters 2002, 3923.
http://dx.doi.org doi:10.1016/S0040-4039(02)00661-5
Publications at Roche:
1. N. K. Dunlap, M. Dezube, D. D. Keith and M. Weigele, "1,1-Dicyanomethylcarbacephems: "Synthesis of a Highly Reactive 1,1-Dicyanomethylene-1-dethiacephalosporin", Tetrahedron Letters 1992, 6103.
http://dx.doi.org doi:10.1016/S0040-4039(00)60017-5
2. A. J. Corraz, S. L. Dax, N. K. Dunlap, N. H. Georgopapadakou, D. D. Keith, D. L. Pruess, P. L. Rossman, R. Then, J. Unowsky and C.-C. Wei, "Dual-Action Penems and Carbapenems", J. Med. Chem. 1992, 35, 1828. http://pubs.acs.org/doi/abs/10.1021/jm00088a019
Patents
1. N. K. Dunlap, D. D. Keith and C.-C. Wei, "Antibacterial Penem Compounds", U. S. Patent Application Serial No. 07/630,694.
Funding
August 2003 (PI) $415,879 National Science Foundation
"400 MHz NMR for Research and Training in Chemical Synthesis"
July 2003 (co-PI) $174,443 National Science Foundation
"Hands-on Experiences with NMR in the Undergraduate Chemistry Curriculum"
June 2003 (PI) $105,00` NIH AREA grant,
"Peptidomimetics of D-Ala-D-Ala as Novel Antibacterials"